Protein Details: Voltage-gated potassium channel subunit beta-3

Protein ID

ICDB_Pro_0214

Protein Name

Voltage-gated potassium channel subunit beta-3

Gene Name

KCNAB3; KCNA3B

Organism

Homo sapiens (Human)

Length

404 amino acids

AlphaFoldDB

AF-O43448-F1-model_v4.pdb

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5

Sequence

MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPAGGGHGNPPGGGGSGPKARAALVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGSVTWYPLACGLITSKYDGRVPDTCRASIKGYQWLKDKVQSEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIEHLGALQVLSQLTPQTVMEIDGLLGNKPHSKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

97; 98; 104; 126; 199; 229; 230; 255; 284; 286; 287; 288; 289; 295; 305; 364; 366; 370; 373

Disease

Li-Fraumeni Syndrome and Cardiomyopathy;Dilated;1C;With Or Without Left Ventricular Noncompaction

Location

Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex; occipital lobe; frontal lobe and temporal lobe. Not detected in spinal cord; heart; lung; liver; kidney; pancreas; placenta and skeletal muscle.

DOI ID

10.1074/jbc.273.52.35095; 10.1101/gr.2596504

RefSeq

NP_004723.2